Nicolas Dzamko Selected Research

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

1/2018	Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers.
1/2017	LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies.
1/2013	Measurement of LRRK2 and Ser910/935 phosphorylated LRRK2 in peripheral blood mononuclear cells from idiopathic Parkinson's disease patients.

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Nicolas Dzamko Research Topics

Disease

38	Parkinson Disease (Parkinson's Disease) 01/2024 - 10/2009
6	Inflammation (Inflammations) 03/2022 - 11/2010
4	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2022 - 10/2013
3	Movement Disorders (Movement Disorder) 01/2024 - 01/2022
3	Disease Progression 01/2023 - 01/2021
3	Insulin Resistance 11/2010 - 12/2004
3	Obesity 11/2010 - 12/2004
2	Synucleinopathies 11/2022 - 01/2017
2	Dementia (Dementias) 11/2022 - 12/2021
2	Alzheimer Disease (Alzheimer's Disease) 11/2022 - 01/2022
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2023
1	Multiple System Atrophy 11/2022
1	Gaucher Disease (Gaucher's Disease) 01/2021
1	Central Nervous System Diseases (CNS Diseases) 10/2013
1	Fatty Liver 11/2010
1	Weight Loss (Weight Reduction) 05/2006
1	Glucose Intolerance 12/2004
1	Type 2 Diabetes Mellitus (MODY) 12/2004

Drug/Important Bio-Agent (IBA)

20	Phosphotransferases (Kinase)IBA 01/2024 - 10/2009
16	Leucine (L-Leucine)FDA Link 01/2024 - 04/2011
11	Proteins (Proteins, Gene)FDA Link 10/2022 - 01/2017
9	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2013
9	SynucleinsIBA 11/2022 - 01/2016
7	Glucosylceramidase (Glucocerebrosidase)IBA 01/2023 - 01/2018
6	LipidsIBA 01/2023 - 12/2004
5	CytokinesIBA 12/2023 - 11/2010
3	CeramidesIBA 01/2023 - 10/2018
3	Leucine-Rich Repeat Serine-Threonine Protein Kinase-2IBA 01/2018 - 01/2013
3	Serine (L-Serine)FDA Link 01/2017 - 10/2009
3	Leucine-Rich Repeat ProteinsIBA 09/2010 - 10/2009
2	SphingomyelinsIBA 01/2024 - 10/2022
2	Triglycerides (Triacylglycerol)IBA 01/2023 - 10/2022
2	HydrolasesIBA 01/2023 - 01/2018
2	Membrane LipidsIBA 11/2022 - 10/2022
2	Insulin (Novolin)FDA Link 10/2022 - 11/2010
2	EnzymesIBA 01/2022 - 10/2018
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2017 - 01/2012
2	Protein Kinases (Protein Kinase)IBA 01/2014 - 10/2009
1	prenolIBA 01/2023
1	Mitochondrial DNA (mtDNA)IBA 01/2023
1	Cholesterol Esters (Cholesteryl Esters)IBA 01/2023
1	phosphatidylethanolamineIBA 01/2023
1	ubiquinone 8IBA 01/2023
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2023
1	AldehydesIBA 11/2022
1	lysophosphatidylethanolamineIBA 10/2022
1	SphingolipidsIBA 10/2022
1	acylcarnitineIBA 10/2022
1	Phosphatidylcholines (Phosphatidylcholine)IBA 10/2022
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2022
1	AutoantibodiesIBA 01/2022
1	Amyloidogenic ProteinsIBA 01/2022
1	ProgranulinsIBA 12/2021
1	alpha-SynucleinIBA 01/2021
1	Toll-Like Receptor 2IBA 01/2017
1	Cathepsin DIBA 01/2016
1	ParaffinIBA 10/2013
1	Formaldehyde (Formol)FDA Link 10/2013
1	I-kappa B KinaseIBA 01/2012
1	LRRK2-IN1IBA 04/2011
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 11/2010
1	SterolsIBA 11/2010
1	LeptinIBA 11/2010
1	Suppressor of Cytokine Signaling 3 ProteinIBA 11/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2010
1	2- methyl- 1- ((4- methyl- 5- isoquinolinyl)sulfonyl)homopiperazineIBA 09/2010
1	Sunitinib (Sutent)FDA Link 09/2010
1	Glucose (Dextrose)FDA LinkGeneric 05/2006
1	Fatty Acids (Saturated Fatty Acids)IBA 05/2006
1	AMP-Activated Protein KinasesIBA 05/2006
1	Ciliary Neurotrophic Factor (CNTF)IBA 05/2006
1	Metformin (Glucophage)FDA LinkGeneric 12/2004

Therapy/Procedure

2	Therapeutics 10/2022 - 07/2019